Vygenerované: 25.10.2026 21:10:10
Súhrn: Active surveillance may be a feasible strategy for improving quality of life and potentially avoiding surgery in patients with locally advanced esophageal cancer who have a clinical complete response to neoadjuvant chemoradiation, according to updated findings from a phase 3 study At a median of 76 months, roughly half of patients in both treatment groups were still alive The findings, presented at the European Society for Medical Oncology 2026 annual meeting in Madrid, build on prior data from the trial showing that active surveillance was non-inferior to surgery in terms of 2-year overall survival.
Doplnenie: However, distant metastases were more common in the active surveillance group, as were deaths from esophageal cancer, specifically.
Súhrn: The HER2-targeted antibody-drug conjugate (ADC) trastuzumab rezetecan more than doubled progression-free survival compared with standard chemotherapy in patients with HER2-low advanced breast cancer in the phase 3 HORIZON-Breast06 trial 8 months with chemotherapy, representing a 73% reduction in the risk for disease progression or death The incidence of interstitial lung disease (ILD), an important safety concern with HER2-directed ADCs, was low.
Doplnenie: 8 months with chemotherapy, representing a 73% reduction in the risk for disease progression or death.
Súhrn: TOPLINE Among postmenopausal women in a large US study, higher body roundness index (BRI) was associated with increased risks of several cancers, including colon, kidney, liver, and lung cancers – even after adjustment for BMI To investigate, researchers examined data from 144,865 postmenopausal women aged 50-79 years enrolled in the Women's Health Initiative, with a median follow-up of 17 METHODOLOGY - BRI reflects abdominal adiposity more accurately than BMI does, but evidence linking BRI to long-term cancer risk is limited.
Doplnenie: - BRI was calculated from waist circumference and height measurements at baseline and at year 3 in 60% of participants.
Súhrn: METHODOLOGY - Researchers conducted a prospective observational study spanning eight tertiary care hospitals in China by including 952 nulliparous women with term, single, cephalic pregnancies who intended to have vaginal delivery with epidural pain relief from June 2021 to February 2022 - Researchers calculated pain intensity as time-weighted average scores, average scores, area under the curve for pain intensity, and peak scores to assess the relationship between analgesic efficacy and intrapartum hyperthermia TOPLINE Nulliparous women who experienced more effective epidural labor analgesia, reflected by lower pain scores, had increased odds of developing intrapartum fever.
Doplnenie: - Axillary temperature was tracked continuously from the start of labor analgesia until the third stage concluded.