Hodinový prehľad - Zdravotnícke a vedecké zaujímavosti

Súhrn: TOPLINE Adding anxiety and suicide risk screening to depression screening in pediatric primary care identified one additional adolescent with moderate or severe mental and behavioral health symptoms for every 13 patients screened METHODOLOGY - Researchers conducted a retrospective study at three academic primary care practices between March and October 2025 - A total of 2776 adolescents completed three mental and behavioral health screeners at well child visits: the Patient Health Questionnaire-9 (PHQ-9) for symptoms of depression, the Ask Suicide Questionnaire (ASQ) for suicide risk, and the Generalized Anxiety Disorder-7 (GAD-7) for symptoms of anxiety.

Súhrn: METHODOLOGY - Researchers retrospectively analyzed a global healthcare database in September 2025, which included data from more than 250 healthcare organizations TOPLINE In a large database analysis, cross-drug reaction among fluoroquinolones (ciprofloxacin, levofloxacin, and moxifloxacin) was rare and only modestly raised subsequent reaction odds for some drug pairs, suggesting class-wide avoidance may be unwarranted and supporting drug challenge as a safe strategy in selected patients - A total of 96,966 patients with ciprofloxacin allergy labels, 64,863 with levofloxacin allergy labels, and 23,117 with moxifloxacin allergy labels were identified through codes linked to relevant antibiotic exposure.

Súhrn: TOPLINE Patients with rheumatoid arthritis (RA) referred through an early arthritis recognition clinic experienced significantly less functional disability and had more than twice the likelihood of sustained disease-modifying antirheumatic drug (DMARD)-free remission over 5 years compared with those referred through regular pathways METHODOLOGY - A single-center, longitudinal, comparative effectiveness cohort study compared patients with RA referred through the early arthritis recognition clinic (recruited between August 2010 and January 2020; n = 122) with those referred through regular pathways (recruited between January 2006 and December 2009; n = 342) - Both groups received treatment in line with recommendations, with methotrexate as first-line therapy, and were followed up prospectively for 5 years at the Leiden Early Arthritis Clinic.

Súhrn: METHODOLOGY - Researchers analyzed active, laboratory- and population-based surveillance data from 20 counties across seven US states to examine annual trends in mortality rates among adult patients with SAB during 2005-2022 both before and during the COVID-19 pandemic - Cases were categorized by epidemiologic class: hospital-onset (HO) if incident culture was collected ≥3 days after hospitalization; healthcare-associated community-onset (HACO) if collected in outpatient setting or <3 days after hospitalization from patients with healthcare risk factors; or community-associated (CA) if none of these criteria were met - Recent SARS-CoV-2 infection was defined as a positive viral test (molecular assay or antigen) ≤30 days before or on the incident SAB culture date, ascertained through medical record review, state reportable disease surveillance systems, and COVID hospitalization surveillance records.

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