Hodinový prehľad - Zdravotnícke a vedecké zaujímavosti

Súhrn: TOPLINE Children and adolescents with obesity who received a combination of drugs and structured lifestyle treatments achieved the largest short-term reductions in BMI METHODOLOGY - Researchers conducted a systematic review and network meta-analysis, searching literature databases through June 2025, to assess obesity treatments that worked best for young people - Interventions included structured behavioral and lifestyle treatments (standard and intensive); counseling; the use of drugs such as GLP-1 receptor agonists, metformin, orlistat, and phentermine-topiramate; and the combination of drugs with lifestyle treatment.

Súhrn: TOPLINE In fit patients with untreated chronic lymphocytic leukemia (CLL), first-line treatment with fixed-duration venetoclax-obinutuzumab was associated with higher undetectable minimal residual disease (MRD) rates than fludarabine, cyclophosphamide, and rituximab/bendamustine-rituximab in the phase 3 CRISTALLO trial METHODOLOGY - Standard first-line options for CLL include chemoimmunotherapy, continuous Bruton tyrosine kinase inhibitor therapy, and fixed-duration venetoclax-based treatment Although undetectable MRD is strongly associated with progression-free and overall survival after fixed-duration therapy, MRD is rarely used as a sole primary endpoint.

Súhrn: METHODOLOGY - Researchers conducted a multicentre retrospective cohort study across 10 tertiary care centres in Italy from January 2023 to May 2025 to assess the role of elevated transaminase levels as a potential biomarker of disease severity and progression in children hospitalised for influenza infection TOPLINE Hypertransaminasaemia or elevated transaminase levels may have served as an early and reliable marker of systemic severity that could have identified children at an increased risk for complications, ICU admission, and mortality - A total of 543 children (mean age, 43 months; 57.

Súhrn: Remote programming of deep brain stimulation (DBS) may expand access to specialist care by allowing clinicians to adjust therapy from a distance and reduce follow-up visits Technology represents another step in the evolution of DBS, which has transformed the treatment of conditions such as Parkinson’s disease, essential tremors, and dystonia How DBS Works A neurostimulator is an implantable medical device that delivers low-intensity electrical impulses to specific brain circuits to reduce symptoms such as tremors, rigidity, and involuntary movements.