Hodinový prehľad - Zdravotnícke a vedecké zaujímavosti

Súhrn: Repeatedly high levels of an Epstein-Barr virus (EBV) antibody on serial blood tests may offer a new way to distinguish multiple sclerosis (MS) from its closest inflammatory mimics — myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD) Results of the case-control study showed the odds of an MS diagnosis were significantly more likely in individuals with serially elevated Epstein-Barr nuclear antigen 1 (EBNA-1) peptide antibody levels — 300 times more likely than a diagnosis of MOGAD and 100 times more likely than NMOSD A small number of patients with neuroinflammatory diseases other than MS also had persistently elevated EBNA-1 peptide antibody levels, and some patients with MS lacked the antibodies altogether.

Súhrn: “Transcatheter mitral valve-in-valve has emerged as a less-invasive therapy for select high-risk patients,” he said NEW ORLEANS — In a clinical trial comparing repeat mitral valve replacement surgery with a transcatheter valve-in-valve approach for dysfunctional bioprosthetic mitral valves, results linked the less invasive technique with a lower rate for death or stroke after 1 year “The difference emerged early in the postoperative period,” said Dimytri Siqueira, MD, PhD, an interventional cardiologist at the Dante Pazzanese Institute for Cardiology in Sao Paulo, Brazil.

Súhrn: “When we talk about holistic interventions that doctors can provide [to lower inflammation and risk of disease in the general population], generally speaking, we talk about nutrition, we talk about exercise, and maybe we talk about sleep,” he told Medscape Medical News “But exercise has by far the most robust evidence, it’s easier to study, and it’s easily prescribable With a small team of other researchers, they are documenting that a 12-week personalized home-based strengthening program utilizing resistance bands — and modifications as needed — can lead to significant improvements in functional strength and endurance without the exercises themselves causing increases in flares.

Súhrn: METHODOLOGY: - Researchers conducted a retrospective study in a real-world observational cohort to assess whether IV methylprednisolone pulses followed by the administration of reduced-dose oral glucocorticoids were a safe and effective initial treatment for GCA - The primary outcome was time to remission, defined as the absence of clinical signs and symptoms of active GCA with normalization of acute-phase reactants, with follow‑up for the first 3 months after starting treatment TOPLINE: In patients newly diagnosed with giant cell arteritis (GCA), the use of short intravenous (IV) pulses of methylprednisolone followed by the administration of a reduced dose of oral prednisone was associated with faster remission and lower overall exposure to steroids than the use of oral prednisone alone.