Vygenerované: 08.12.2025 16:20:11
Súhrn: Another benefit that is gaining interest is the effect these medications have on inflammation, and the potential role for this effect in the treatment of type 2 diabetes (T2D) and other conditions “I’m quite convinced…that treatment of inflammation is going to become part of our treatment [of T2D],” said Marc Y Donath, MD, medical director of the Centre d’Excellence Intégré en Santé Métabolique at the University Hospital Montreal, Montreal, in his presentation at Diabetes Canada and Canadian Society of Endocrinology and Metabolism (CSEM) Professional Conference 2025.
Doplnenie: Donath, MD, medical director of the Centre d’Excellence Intégré en Santé Métabolique at the University Hospital Montreal, Montreal, in his presentation at Diabetes Canada and Canadian Society of Endocrinology and Metabolism (CSEM) Professional Conference 2025.
Súhrn: But “an emerging concern of these therapies is the unintended loss of skeletal muscle mass, which has important implications for metabolic health, physical function, and long-term outcomes,” said Jenna Gillen, PhD, assistant professor of exercise physiology at the University of Toronto, Toronto ” A 2021 study published in Diabetes, Obesity and Metabolism found that semaglutide reduced food intake in people with type 2 diabetes and affected appetite and food preference, including by shifting participants away from consumption of sweet or high-fat foods TORONTO — GLP-1 receptor agonists (RAs) have transformed diabetes and obesity management, offering improvements in glycemic control and weight loss and reductions in cardiometabolic risk.
Doplnenie: In mouse studies, the pronounced weight loss due to GLP-1s “seems to be explained to a large extent by reductions in food intake, at least during the initial week or two,” David Wright, PhD, professor of kinesiology at the University of British Columbia in Vancouver, said during the session’s first presentation.
Súhrn: - Home - Medical news & Guidelines - Anesthesiology - Cardiology and CTVS - Critical Care - Dentistry - Dermatology - Diabetes and Endocrinology - ENT - Gastroenterology - Medicine - Nephrology - Neurology - Obstretics-Gynaecology - Oncology - Ophthalmology - Orthopaedics - Pediatrics-Neonatology - Psychiatry - Pulmonology - Radiology - Surgery - Urology - Laboratory Medicine - Diet - Nursing - Paramedical - Physiotherapy - Health news - Fact Check - Bone Health Fact Check - Brain Health Fact Check - Cancer Related Fact Check - Child Care Fact Check - Dental and oral health fact check - Diabetes and metabolic health fact check - Diet and Nutrition Fact Check - Eye and ENT Care Fact Check - Fitness fact check - Gut health fact check - Heart health fact check - Kidney health fact check - Medical education fact check - Men's health fact check - Respiratory fact check - Skin and hair care fact check - Vaccine and Immunization fact check - Women's health fact check - AYUSH - State News - Andaman and Nicobar Islands - Andhra Pradesh - Arunachal Pradesh - Assam - Bihar - Chandigarh - Chattisgarh - Dadra and Nagar Haveli - Daman and Diu - Delhi - Goa - Gujarat - Haryana - Himachal Pradesh - Jammu & Kashmir - Jharkhand - Karnataka - Kerala - Ladakh - Lakshadweep - Madhya Pradesh - Maharashtra - Manipur - Meghalaya - Mizoram - Nagaland - Odisha - Puducherry - Punjab - Rajasthan - Sikkim - Tamil Nadu - Telangana - Tripura - Uttar Pradesh - Uttrakhand - West Bengal - Medical Education - Industry Non-invasive closed-loop spinal stimulation enables paraplegic patients to regain stepping control Spinal cord injury (SCI) rostral to the lumbar locomotor center disrupts communication between the brain and the spinal circuits that control leg movements, leading to paraplegia A research team led by Dr Yukio Nishimura of the Tokyo Metropolitan Institute of Medical Science, in collaboration with Dr.
Doplnenie: Toshiki Tazoe and colleagues, has now demonstrated a novel noninvasive closed-loop spinal stimulation paradigm that restores stepping control in humans with paraplegia.
Súhrn: There are “clear failings” in how GPs assess and support older people living with frailty, with unexplained variation in practice across England, according to the National Audit Office (NAO) The report described frailty as “one of the greatest challenges facing the NHS” Improvements could be “a massive gamechanger”, boosting care quality and freeing up hospital capacity.
Doplnenie: Frailty occurs when the ageing process causes multiple physiological systems to lose resilience.
Súhrn: TOPLINE: Non-operative management achieved 95% distant relapse-free survival at 30 months in patients with stage II-III rectal cancer showing a clinical complete response to total neoadjuvant therapy, while maintaining successful salvage surgery options among 15% of those who experienced local regrowth according to a phase 2 trial METHODOLOGY: - Researchers conducted an investigator-driven, multicentre, single-arm, phase 2 trial enrolling 180 patients (median age, 62 years; 44% women) with stage II-III adenocarcinoma of the lower-to-middle rectum across four cancer centres in Italy from June 2018 to August 2023 - Treatment consisted of induction chemotherapy with four cycles of capecitabine (1000 mg/m2 orally twice daily on days 1-14 every 3 weeks) and oxaliplatin (130 mg/m2 intravenously on day 1 every 3 weeks), followed by chemoradiotherapy with 50-54 Gy in 25 fractions for 5 weeks.
Doplnenie: - The analysis included 179 evaluable patients: 47 (26%) who achieved a clinical complete response were assigned to non-operative management, 107 (60%) underwent surgery after therapy, and 18 (10%) underwent surgery after study discontinuation.
Súhrn: - Home - Medical news & Guidelines - Anesthesiology - Cardiology and CTVS - Critical Care - Dentistry - Dermatology - Diabetes and Endocrinology - ENT - Gastroenterology - Medicine - Nephrology - Neurology - Obstretics-Gynaecology - Oncology - Ophthalmology - Orthopaedics - Pediatrics-Neonatology - Psychiatry - Pulmonology - Radiology - Surgery - Urology - Laboratory Medicine - Diet - Nursing - Paramedical - Physiotherapy - Health news - Fact Check - Bone Health Fact Check - Brain Health Fact Check - Cancer Related Fact Check - Child Care Fact Check - Dental and oral health fact check - Diabetes and metabolic health fact check - Diet and Nutrition Fact Check - Eye and ENT Care Fact Check - Fitness fact check - Gut health fact check - Heart health fact check - Kidney health fact check - Medical education fact check - Men's health fact check - Respiratory fact check - Skin and hair care fact check - Vaccine and Immunization fact check - Women's health fact check - AYUSH - State News - Andaman and Nicobar Islands - Andhra Pradesh - Arunachal Pradesh - Assam - Bihar - Chandigarh - Chattisgarh - Dadra and Nagar Haveli - Daman and Diu - Delhi - Goa - Gujarat - Haryana - Himachal Pradesh - Jammu & Kashmir - Jharkhand - Karnataka - Kerala - Ladakh - Lakshadweep - Madhya Pradesh - Maharashtra - Manipur - Meghalaya - Mizoram - Nagaland - Odisha - Puducherry - Punjab - Rajasthan - Sikkim - Tamil Nadu - Telangana - Tripura - Uttar Pradesh - Uttrakhand - West Bengal - Medical Education - Industry APT-Sepsis Program Lowers Severe Infection-Related Maternal Outcomes: NEJM UK: Researchers have found in a new study that implementation of the APT-Sepsis program significantly reduced the risk of infection-related maternal death, near-miss events, and severe infection-related illness compared with usual care Published in the New England Journal of Medicine, the study led by David Lissauer of the Institute of Life Course and Medical Sciences, University of Liverpool, highlights the potential of a structured, evidence-based approach to transform maternal infection outcomes in low-resource settings Maternal infection and sepsis remain among the leading causes of preventable maternal mortality worldwide, particularly in low- and middle-income countries, where gaps in early detection, adherence to hygiene standards, and consistent treatment often lead to delayed or inadequate care.
Doplnenie: To address these challenges, the researchers conducted a cluster-randomized trial assessing the Active Prevention and Treatment of Maternal Sepsis (APT-Sepsis) program.
Súhrn: - Home - Medical news & Guidelines - Anesthesiology - Cardiology and CTVS - Critical Care - Dentistry - Dermatology - Diabetes and Endocrinology - ENT - Gastroenterology - Medicine - Nephrology - Neurology - Obstretics-Gynaecology - Oncology - Ophthalmology - Orthopaedics - Pediatrics-Neonatology - Psychiatry - Pulmonology - Radiology - Surgery - Urology - Laboratory Medicine - Diet - Nursing - Paramedical - Physiotherapy - Health news - Fact Check - Bone Health Fact Check - Brain Health Fact Check - Cancer Related Fact Check - Child Care Fact Check - Dental and oral health fact check - Diabetes and metabolic health fact check - Diet and Nutrition Fact Check - Eye and ENT Care Fact Check - Fitness fact check - Gut health fact check - Heart health fact check - Kidney health fact check - Medical education fact check - Men's health fact check - Respiratory fact check - Skin and hair care fact check - Vaccine and Immunization fact check - Women's health fact check - AYUSH - State News - Andaman and Nicobar Islands - Andhra Pradesh - Arunachal Pradesh - Assam - Bihar - Chandigarh - Chattisgarh - Dadra and Nagar Haveli - Daman and Diu - Delhi - Goa - Gujarat - Haryana - Himachal Pradesh - Jammu & Kashmir - Jharkhand - Karnataka - Kerala - Ladakh - Lakshadweep - Madhya Pradesh - Maharashtra - Manipur - Meghalaya - Mizoram - Nagaland - Odisha - Puducherry - Punjab - Rajasthan - Sikkim - Tamil Nadu - Telangana - Tripura - Uttar Pradesh - Uttrakhand - West Bengal - Medical Education - Industry FDA Approves Acellular Nerve Allograft for Sensory Nerve Repair The FDA has approved Avance® (acellular nerve allograft-arwx) for treating sensory nerve discontinuity , Chief Medical and Scientific Officer and Director of the FDA’s Center for Biologics Evaluation and Research “Current treatment options, such as autografts, have limitations, so this approval addresses a significant unmet medical need for patients with peripheral nerve injuries.
Doplnenie: Avance is a peripheral nerve scaffold approved for sensory nerve discontinuities (≤25mm) (breaks in the pathway of sensory nerves) in adults and pediatric patients aged one month and older.
Súhrn: - Home - Medical news & Guidelines - Anesthesiology - Cardiology and CTVS - Critical Care - Dentistry - Dermatology - Diabetes and Endocrinology - ENT - Gastroenterology - Medicine - Nephrology - Neurology - Obstretics-Gynaecology - Oncology - Ophthalmology - Orthopaedics - Pediatrics-Neonatology - Psychiatry - Pulmonology - Radiology - Surgery - Urology - Laboratory Medicine - Diet - Nursing - Paramedical - Physiotherapy - Health news - Fact Check - Bone Health Fact Check - Brain Health Fact Check - Cancer Related Fact Check - Child Care Fact Check - Dental and oral health fact check - Diabetes and metabolic health fact check - Diet and Nutrition Fact Check - Eye and ENT Care Fact Check - Fitness fact check - Gut health fact check - Heart health fact check - Kidney health fact check - Medical education fact check - Men's health fact check - Respiratory fact check - Skin and hair care fact check - Vaccine and Immunization fact check - Women's health fact check - AYUSH - State News - Andaman and Nicobar Islands - Andhra Pradesh - Arunachal Pradesh - Assam - Bihar - Chandigarh - Chattisgarh - Dadra and Nagar Haveli - Daman and Diu - Delhi - Goa - Gujarat - Haryana - Himachal Pradesh - Jammu & Kashmir - Jharkhand - Karnataka - Kerala - Ladakh - Lakshadweep - Madhya Pradesh - Maharashtra - Manipur - Meghalaya - Mizoram - Nagaland - Odisha - Puducherry - Punjab - Rajasthan - Sikkim - Tamil Nadu - Telangana - Tripura - Uttar Pradesh - Uttrakhand - West Bengal - Medical Education - Industry Maternal Antibiotic Use Linked to Childhood Cancer; Prenatal Supplements May Reduce Risk: Study The use of medication during pregnancy carries a potential health risk, including childhood cancer, for the unborn child Meta-analyses were conducted if ≥ 3 studies on the same research question were available to calculate pooled estimates for random effects models with 95% confidence intervals (CI) The I2 statistic was calculated to quantify between-study heterogeneity.
Doplnenie: Studies with exposure to diethylstilbestrol as a known teratogen were excluded.
Súhrn: Dobré ránko! Leto sa nám pomaly končí, ale nesmúť, je tu nový Imuno MD Čo ťa dnes čaká? Pozrieme sa na varovné príznaky vrodených porúch imunity a na možnosti kombinácie alergénovej imunoterapie a biologickej liečby v manažmente inhalačnej alergie Počul*a si už o syndróme VEXAS? V dnešnom imunokvíze si overíme, čo o ňom vieš.
Doplnenie: 😁 S prípravou dnešného newslettra mi pomohla Otília Petrovičová.
Súhrn: Dobré ránko! Vitaj v júlovom Imuno MD! Dnes ráno sa rozcvičíme hádankou: Horúčky, lymfadenopatia, faryngitídy a afty, ale infekcia to nie je Čo je to? Ak si pediater alebo imunológ, správnu odpoveď určite poznáš Ak náhodou odpovedať nevieš, čítaj ďalej 😊 Keďže je odpoveď veľmi ľahká, čaká ťa aj ďalšia otázka v Imuno kvíze – posvietime si na kliešte.
Doplnenie: V aktuálnej štúdii sa pozrieme na to, či je možné zvrátiť remodeláciu pri astme.
Súhrn: 'Life being stressful is not an illness' - GPs on mental health over-diagnosis Hundreds of GPs across England have told the BBC they think mental health problems are being over-diagnosed One commonly-held view by family doctors, our research suggests, is that society tends to over-medicalise normal life stresses But they're also concerned about how hard it is to get help for patients with mental health conditions.
Doplnenie: Earlier this week, the Health Secretary ordered an independent review into the reasons for a rising demand for mental health, ADHD and autism services in England, and where the gaps in support are.
Súhrn: Medical doctor Dr Oscar Duke, who is also a regular TV presenter including on the BBC's Morning Live, shares his top tips to spot the difference and avoid the worst: Does colder weather cause colds? Research on the extent to which cold weather impacts our immune systems remains unclear Is it a cold, 'super flu' or Covid? How to tell the difference Chances are you know someone coughing and spluttering - hopefully not directly on you - right now There are lots of coughs and colds doing the rounds as autumn draws in.
Doplnenie: Medical doctor Dr Oscar Duke, who is also a regular TV presenter including on the BBC's Morning Live, shares his top tips to spot the difference and avoid the worst: Does colder weather cause colds? Research on the extent to which cold weather impacts our immune systems remains unclear.
Súhrn: Dobré ránko Vitaj v júnovom Imuno MD! Dnes sa pozrieme na novú klasifikáciu vrodených porúch imunity, v kvíze odhalíme nebezpečenstvo, ktoré na nás číha v palacinkách a vrátime sa k anafylaxii V dnešnom Imuno MD: 📔 Nová klasifikácia vrodených porúch 🥞 Pancake syndróm 💉 Manažment anafylaxie Užívaj! Aktuálna imuno štúdia v skratke 📔 Dočkali sme sa aktualizovanej klasifikácie vrodených porúch imunity! IUIS (International Union of Immunological Societies) každé dva roky aktualizuje klasifikáciu vrodených porúch imunity vrátane fenotypovej klasifikácie.
Doplnenie: Od poslednej aktualizácie pribudlo 67 vrodených porúch imunity (IEI, inborn errors of immunity) a 2 fenokópie.
Súhrn: New mpox strain identified in England A new strain of mpox, previously called monkeypox, has been detected in a person in England, say UK health officials The UK Health Security Agency (UKHSA) says it is normal for viruses to evolve Getting vaccinated remains the best way to protect against severe disease - although an mpox infection is mild for many.
Doplnenie: The UK Health Security Agency (UKHSA) says it is normal for viruses to evolve.
Súhrn: TOPLINE: In patients with axial spondyloarthritis (axSpA), a higher intake of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with reduced radiographic spinal progression, particularly in those with radiographic disease METHODOLOGY: - Researchers investigated whether the intake of NSAIDs affected the radiographic spinal progression in patients with axSpA, using data from a German cohort - They included 252 patients with axSpA (139 with non-radiographic and 113 with radiographic disease; mean age, 35.
Doplnenie: 9 years; 50% men).
Súhrn: Bližšie sa pozrieme práve na nich: 🔄 U všetkých pacientov bola indikovaná substitúcia imunoglobulínov (IgRT, immunoglobulin replacement therapy ), vďaka čomu ani jeden z nich neprekonal infekciu so závažným priebehom Ahoj! Keďže vonku sa nám značne ochladilo, zahrejeme sa témou z oblasti Stredozemného mora Tušíš správne, bude to o autoinflamácii.
Doplnenie: V dnešnom Imuno MD: 🧬 Nový pohľad na IGLL1 deficit 📝 Imuno kvíz 🔥 Familiárna stredomorská horúčka v praxi Užívaj! Aktuálna imuno štúdia v skratke 🧬 Nečakane vysoká incidencia zriedkavej poruchy imunity Nedávno sme si posvietili na skríning vrodených porúch imunity.
Súhrn: Teens as young as 15 seeking help over botched Botox and fillers Teenagers as young as 15 are seeking help after receiving botched Botox treatment and fillers, a charity has said The Scottish government has proposed legislation to make non-surgical treatments illegal for under-18s and require procedures to be carried out in approved premises The charity's submission to Holyrood's Health, Social Care and Sport Committee stated: "We have received complaints about some practitioners carrying out dermal filler and Botox injections on customers as young as 15.
Doplnenie: ADS, which runs the website consumeradvice.
Súhrn: Podání přihlášky - Vyplňte formulář přihlášky (najdete v sekci Formuláře) - Přihlášku můžete podat: - na studijní pobyt, - na praktickou stáž, - nebo na oba typy pobytů - Termín pro podání přihlášky: 15.
Doplnenie: 2026 Přihlášku můžete odevzdat: - osobně Anně Jezberové ze Zahraničního oddělení 1.